Glycine (120 Capsules)

General Health Support - Natural Herbal Dietary Supplement*

Glycine Health Support for:

• Healthy Cellular Function *
• Cellular Hyper-Excitability *
• Cellular Detoxification *

Glycine is a protein amino acid found in the protein of all life forms. It is the simplest amino acid in the body. Although most glycine is found in proteins, free glycine is found in body fluids as well as in plants. The normal diet contributes approximately 2 grams of glycine daily. *

Glycine is of major importance in the synthesis of proteins, peptides, purines, adenosine triphosphate (ATP), nucleic acids, porphyrins, hemoglobin, glutathione, creatine, bile salts, one-carbon fragments, glucose, glycogen, and L-serine and other amino acids. Glycine is also a neurotransmitter in the central nervous system (CNS). Glycine and gamma-aminobutyric acid (GABA) are the major inhibitory neurotransmitters in the CNS. Recently, a glycine-gated chloride channel has been identified in neurophils that can attenuate increases in intracellular calcium ions and diminish oxidant damage mediated by these white blood cells. Thus, glycine may be a novel antioxidant. *

High-dose glycine may be beneficial in the management of enduring negative symptoms of schizophrenia. Twenty-two treatment-resistant schizophrenic patients participated in a double-blind, placebo-controlled, six-week, crossover treatment trial with 0.8 grams per kilogram daily of glycine added to their ongoing antipsychotic medication. Glycine intake ranged from 40 to 90 grams daily. Only mild gastrointestinal side effects (nausea and vomiting) were reported in one patient taking glycine. Patients taking glycine experienced significantly diminished negative symptoms. *

Recent animal studies suggest that glycine may have some anti-cancer properties. In one recent study, 51 weeks of glycine supplementation did not stop early foci formation of cancer but reduced formation of small liver tumors by 23%, medium-sized tumors by 64% and large tumors by nearly 80% in rats given an agent that is a peroxisome proliferator and liver carcinogen.* <

In another recent study, dietary glycine inhibited B16 melanoma tumors in mice. Glycine-supplemented mice had tumors that were 50 to 70% smaller in size than those in controls. The protective mechanism in this case appeared to be inhibition of angiogenesis effected by suppressed endothelial-cell proliferation. Tumors in mice fed glycine had 70% fewer arteries than were present in the tumors of controls. *

Suggested Usage: As a Dietary Supplement, take 2 capsules twice daily on an empty stomach, 30 minutes before meals, or as directed by a healthcare practitioner.
Ingredients: L-Glycine
Count: 120 Vegetarian Capsules
Net Weight per Capsule: 750 mg.
Servings Per Bottle: Approx. 60 Servings

REFERENCES

1. de Kooning JT, Duran M, Dorling L, et al. Beneficial effects of L-serine and glycine in the management of seizures in 3-phosphoglycerate dehydrogenase deficiency. Ann Neurol. 1998; 44:261-265.
2. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999; 56:29-36.
3. Rose ML, Cattley RC, Dunn C, et al. Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14, 643. Carcinogenesis. 1999; 20:2075-2081.
4.Rose ML, Madren J, Bunzendahl H, Thurman RG. Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis. 1999; 20:793-798