I.T.P. Idiopathic Thrombocytopenic Purpura

What is ITP?

I.T.P. (Idiopathic Thrombocytopenic Purpura), also known as Immune Thrombocytopenic Purpura, is classified as an autoimmune disease with symptoms of low platelets and with no known cause (idiopathic, according to western medicine).

 

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What are the Symptoms of ITP?

A person with too few platelets bruises easily, can bleed for a long period of time after being injured and may also have nosebleeds that are hard to stop. Bruising may also take longer to heal. Petechiae is another symptoms of I.T.P. and comes in the form of tiny red dots on the skin.

The average healthy person has 150,000 to 300,000 platelets in each milliliter of blood. For those with I.T.P, platelet counts can often drop to levels as low as 1,000-20,000 platelets/L. Each year, there are 50-100 new cases of ITP per million people and children account for half of that amount.

In people with I.T.P. the blood cells are normal except for the blood platelets. Platelets are tiny blood cells with irregularly-shapes that are produced in the bone marrow and whose main function is to control bleeding and form clots from cuts and wounds. Platelets take part in the blood clotting process (coagulation).

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What is Autoimmune ITP?

In an autoimmune disease the body mounts an attack toward one or more otherwise normal organ systems. In ITP, platelets are the target. People with I.T.P. form antibodies that can destroy their platelets. In healthy individuals, antibodies are a healthy response to toxins like bacteria or viruses. For those with ITP, however, the antibodies attack the body's own blood platelets and are destroyed and recycled in the spleen.

An adequate number of normally functioning platelets is needed for people with I.T.P. to prevent leakage of red blood cells from apparently uninjured vessels as well to prevent a hemorrhage. Extra care and support is needed for those experiencing I.T.P. types of symptoms.

Additional Information: "PDSA which stands for Platelet Disorder Support Association, described a commonly used drug named Rituxan. Click here to read about what they found".

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More Information on Idiopathic Thrombocytopenic Purpura

Idiopathic thrombocytopenic purpura (ITP) is a bleeding condition in which the blood doesn't clot as it should. This is due to a low number of blood cell fragments called platelets (PLATE-lets).

Platelets also are called thrombocytes (THROM-bo-sites). They're made in your bone marrow along with other kinds of blood cells. Platelets stick together (clot) to seal small cuts or breaks on blood vessel walls and stop bleeding.

"Idiopathic" (id-ee-o-PATH-ick) means that the cause of the condition isn't known. "Thrombocytopenic" (throm-bo-cy-toe-PEE-nick) means there's a lower than normal number of platelets in the blood. "Purpura" (PURR-purr-ah) refers to purple bruises caused by bleeding under the skin.

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ITP Overview

People who have ITP often have purple bruises that appear on the skin or on the mucous membranes (for example, in the mouth). The bruises mean that bleeding has occurred in small blood vessels under the skin.

A person who has ITP also may have bleeding that results in tiny red or purple dots on the skin. These pinpoint-sized dots are called petechiae (peh-TEE-kee-ay). Petechiae may look like a rash.

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Petechiae and Purpura

The photograph shows petechiae (red/purple dots) and purpura (bruises) in the skin. Bleeding under the skin causes the purple, brown, and red color of the petechiae and purpura.

People who have ITP also may have nosebleeds, bleeding from the gums when they have dental work done, or other bleeding that's hard to stop. Women who have ITP may have menstrual bleeding that's heavier than usual.

More extensive bleeding can cause hematomas (he-mah-TO-mas). A hematoma is a collection of clotted or partially clotted blood under the skin. It looks or feels like a lump.

Bleeding in the brain as a result of ITP is very rare, but can be life threatening if it occurs.

In most cases, an autoimmune response is believed to cause ITP. Normally your immune system helps your body fight off infections and diseases. But if you have ITP, your immune system attacks and destroys its own platelets. The reason why this happens isnt known.

ITP can't be passed from one person to another.

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Types of Idiopathic Thrombocytopenic Purpura

There are two types of ITP: acute (temporary or short-term) and chronic (long-lasting).

Acute ITP generally lasts less than 6 months. It mainly occurs in children, both boys and girls, and is the most common type of ITP. Acute ITP often occurs after an infection caused by a virus.

Chronic ITP is long-lasting (6 months or longer) and mostly affects adults. However, some teenagers and children can get this type of ITP. Chronic ITP affects women 2 to 3 times more often than men.

Treatment depends on how severe the bleeding symptoms are and the platelet count. In mild cases, treatment may not be needed.

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ITP Prognosis & Outlook

For most children and adults, ITP isn't a serious or life-threatening condition.

Acute ITP in children often goes away on its own within a few weeks or months and doesn't return. In 80 percent of children who have ITP, the platelet count returns to normal within 6 to 12 months. Treatment may not be needed.

A small number of children, about 5 percent, whose ITP doesn't go away on its own may need to have further medical or surgical treatment.

Chronic ITP will vary with each individual and can last for many years. Even people who have severe forms of chronic ITP can live for decades. Most people who have chronic ITP are able at some point to stop treatment and keep a safe platelet count.

Revised June 2009

Source http://www.nhlbi.nih.gov/health/dci/Diseases/Itp/ITP_WhatIs.html

 

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